“Far and away the best prize that life offers is the chance to work hard at work worth doing.” – Theodore Roosevelt, 26th President of the United States

HSC is proud to publish the work of our Fellows and contributing associates in this section. We believe strongly in the dedicated work done by those we publish and are privileged to share their research. We believe that much of the work herein cited is derived from an intense desire to make a difference, find answers and a commitment to scientific inquiry. The noted French Microbiologist and Chemist Louis Pasteur, remembered for his remarkable breakthroughs in the causes and preventions of diseases said “Let me tell you the secret that has led me to my goals: my strength lies solely in my tenacity.” This tenacity is apparent in many of the works we are honored to publish.

Click any of the links below to review the various publications and sponsored projects of HSC.

Research Conducted and Papers Prepared by HSC Fellows

The following is a sample of published papers:

C Calibration Protocol

Contributed by Senior Fellow Dr. Russell M. Jaffe, MD, Ph.D., CCN, this paper provides instruction on how to conduct an Ascorbate (Vitamin C) Calibration Protocol (“C Cleanse”) to determine individual, functional need for ascorbate in order to enhance sustainable health.
The recommended form of “ascorbate” is a 100-percent l-ascorbate, fully reduced, buffered mineral ascorbate form of vitamin C that contains a proper balance of the major essential buffering minerals: 1) potassium, 2) magnesium, 3) calcium, and 4) zinc. As healing occurs and health becomes more balanced, the amounts of ascorbate needed will change accordingly. This paper explains the determining factors for the proper application and use of the protocol.

Contributed by Senior Fellow Dr. Russell M. Jaffe, MD, Ph.D., CCN, this paper discusses the intravenous vitamin c administration protocol.

One, two or three infusions per day may be necessary to reach both target peak and trough levels. Peak and trough blood ascorbate levels are drawn before (for trough) and after (for peak, from the contralateral arm) the 2nd infusion and sent for analysis for plasma ascorbate.

Bioactive Food as Dietary Interventions for Liver and Gastrointestinal Disease: The Alkaline Way in Digestive Health

Excerpted from the recent book contribution by Senior Fellow Dr. Russell M. Jaffe, MD, Ph.D., CCN investigating the use of bioactive food as a therapy in treating liver and gastrointestinal diseases, this chapter focuses on the Alkaline Way as related to digestive health.

The biochemical consequences of diet are the greatest influence on overall metabolism for most patients. Food choices clearly affect the course of common pathophysiological errors such as insulin resistance, metabolic syndrome, and their sequella. However, these dynamics can also be considered a leverage point – an opportunity to reverse immune reactivity through practical interventions that patients can implement in their daily lives.

Bioactive Food as Dietary Interventions for Liver and Gastrointestinal Disease: Functional Assessment of Gastrointestinal Health

Excerpted from the recent book contribution by Senior Fellow Dr. Russell M. Jaffe, MD, Ph.D., CCN investigating the use of bioactive food as a therapy in treating liver and gastrointestinal diseases, this chapter focuses on functional assessments.
Digestion is a series of sophisticated metabolic processes that convert plant carbohydrates, proteins, fats, and other nutrients into building blocks that the body can utilize for nourishment, growth, and repair when toxin load and stress hormones permit. Healthy digestion produces molecular building blocks that support immune system tolerance and enable proactive repair. Multiple mechanisms exclude trap and neutralize larger molecules that can be bioactive and sometimes immunogenic.

Bioactive Food as Dietary Interventions for Cardiovascular Disease: Cardioprotective Nutrients

Excerpted from the recent book contribution by Senior Fellow Dr. Russell M. Jaffe, MD, Ph.D., CCN investigating the use of bioactive food as a therapeutic intervention for treatment of cardiovascular disease, this chapter focuses on cardioprotective nutrients.
A range of foods and bioavailable supplements are now available that provide better outcomes and clinically significant leverage in managing the pathophysiology of cardiovascular disease. Targeted supplementation, in combination with individualized diet therapy, are included as are mental and physical exercises aimed at evoking healing responses in proportion to documented risk reductions.

Bioactive Food as Dietary Interventions for Diabetes: Diabetes as an Immune Dysfunction Syndrome

Excerpted from the recent book contribution by Senior Fellow Dr. Russell M. Jaffe, MD, Ph.D., CCN investigating the use of bioactive food as a therapeutic intervention for the treatment of diabetes, this chapter focuses on how diabetes can be an immune dysfunction.
Diabetes afflicts over 250 million people worldwide. Impaired glucose tolerance affects millions. This trend is projected to add an additional 220 millions before 2050. While diabetes kills too many and accounts for about half of disease care costs, it is a choice. Newly developed ultra-low glycemic balanced 200 calorie meals provide better options that can maintain healthier blood sugar levels for hours after consumption through higher fiber and nutrient dense ingredients.

Bioactive Food as Dietary Interventions for Diabetes: Phytonutrients in Diabetes Management

Excerpted from the recent book contribution by Senior Fellow Dr. Russell M. Jaffe, MD, Ph.D., CCN investigating the use of bioactive food as a therapeutic intervention for the treatment of diabetes, this chapter focuses on how phytonutrients can be effective in management of diabetes.
This chapter discusses various nutrients found beneficial in the clinical management of diabetes. Individual needs can now be determined through functional, predictive tests whose ranges are set to reflect maximum risk reduction or health gained. This approach requires a detailed review of patient history and current situation. Personalized predictive care of diabetics is described here. Over 90% of diabetes risk is avoidable or reversible when healthier life style choices are practiced.

Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases: The Alkaline Way-Integrative Management of Rheumatoid Arthritis and Other Autoimmune Conditions

Excerpted from the recent book contribution by Senior Fellow Dr. Russell M. Jaffe, MD, Ph.D., CCN investigating the use of bioactive food as a therapeutic intervention for arthritis and related inflammatory diseases, this chapter focuses on the benefical aspects of the Alkaline Way in the integrated management of rheumatoid arthritis, etc.
Decades of research on immune function have shown that healthy immune systems are tolerant, resilient, responsive, and competent. Conversely, unhealthy immune systems tend to be intolerant, restricted, indiscriminate, and imbalanced. Yet at present, despite our expanded knowledge of immune function, autoimmune (AI) disorders and chronic illness are becoming more and more prevalent. In the US, for example, more than half of all adults and a rapidly growing proportion of children experience some type of health condition that reflects immune compromise.

Predictive Biomarker Tests: Use and Application for Evidence-based Care

Presentation by Senior Fellow Dr. Russell M. Jaffe, MD, Ph.D., CCN, investigating the role of Predictive Biomarker testing, their use and importance in practice, and the correlation of results towards long-term health.
This presentation provides a detailed overview of Predictive Biomarker Test objectives including how science philosophy influences what society observes and uses, how test interpretations can reference least risk or highest gain goal values rather than usual statistical ranges, and how test results can be translated into quality life years sacrificed/recoverable.

In addition to the above presentation, a special reference table for Predictive Biomarker Tests can be accessed by clicking here.

Diabetes: Food and Nutrients in Primary Practice

Chapter excerpt from Ingrid Kohlstadt’s book “Food and Nutrients in Disease Management” by Senior Fellow Russell M. Jaffe, MD, Ph.D., CCN and Jayashree Mani, MS, CCN.

This chapter provides a contemporary overview of diabetes. Dietary patterns and nutrients that can improve glucose-insulin-energy function are emphasized. Strategic food choices and adequate essential nutrients improve outcomes in people with the continuum from metabolic syndrome to diabetes. Cellular metabolic homeostasis is disrupted long before diabetes becomes clinically apparent by elevated blood glucose or insulin. A direct consequence of these metabolic disturbances is free radical oxidative damage secondary to nutrient deficits detailed in this chapter. …

Polyphenolics Evoke Healing Responses 

Clinical evidence and role of predictive biomarkers

Polyphenolics occur by the thousands, giving color and antioxidant protection to plants and animals. Quercetin dihydrate and soluble orthoproanthocyanidins (sOPC) are preferred, safer polyphenolics as supplements. Consumption can be many grams daily, more than all other classes of phytonutrients. Amounts ingested are typically B10 times higher than the usual dietary intake of vitamin C and 100 times higher than the intake of vitamin E and carotenoids. The primary dietary sources are fruits, colorful vegetables, and plant-derived beverages such as dark chocolate, fruit spritzers, teas, coffees, beers, and wines. Vegetables, cereals, root vegetables, and dry legumes also contribute to the total polyphenolic intake.

Polyphenolics Evoke Healing Responses Chapter 29: Clinical Evidence and Role of Predictive Biomarkers


Anthropogenic Influences on Biology and the Biota, and Connections to Autism Spectrum Disorders

A timely article by Dr. Russell M. Jaffe and Dr. Norman Schwartz that rethinks conventional understandings of autism from a multidisciplinary, integrative, and functional perspective. It draws on the disciplines of integrative physiology, molecular biology, environmental toxicology, and systems dynamics.

Autism spectrum disorder (ASD) is one of several neurodevelopmental disorders that have increased over 100-fold in less than a century, particularly in the developed world. Over this time period, an unprecedented two-way experiment between humans and the natural world has been under way. As human activity reaches the point where it is affecting planetary ecosystems, the sum of local human choices has delivered unforeseen consequences often extending far beyond their source. The outcome of this neither controlled nor blind experiment raises questions about the quality, diversity, and sustainability of life on earth….

Reinventing Fire: Bold Business Solutions for the New Energy Era

Amory Lovins, Senior Fellow of HSC and Executive Director of the Rocky Mountain Institute, is one of the world’s leading experts on energy solutions and sustainability. HSC is pleased to share an overview of Lovins’ book “Reinventing Fire”, along with a paper, and a selection of multimedia.

America’s seemingly two-billion-dollar-a-day oil habit actually costs upwards of three times that much—six billion dollars a day, or a sixth of GDP. That’s due to three kinds of hidden costs, each about a half-trillion dollars per year: the macro economic costs of oil dependence, the microeconomic costs of oil-price volatility, and the military costs of forces whose primary mission is intervention in the Persian Gulf. Those military costs are about ten times what we pay to buy oil from the Persian Gulf, and rival total defense spending at the height of the Cold War. Any costs to health, safety, environment, security of energy supply, world stability and peace, or national independence or reputation are extra. …

The Serotonin Connection

Published in the Journal of Orthomolecular Medicine, this article by Senior Fellow Dr. Robert A. Nash, MD, investigates the connections between serotonin and health.

Serotonin metabolism is disordered in a variety of clinical states. These include addictions, attention deficit disorder, chronic pain, depression, dysthymia, eating disorders, headache, obsessive-compulsive disorders, panic, poor impulse control, post-traumatic stress disorders, premenstrual syndrome, sleep disorders, stress disorders, sudden cardiac death and violence. A decreased serotonin state has also been implicated in sleep disorders which may then progress into dysthymia and depression. Serotonin can be altered by a variety of means, including acupuncture, body work, cranial electrical stimulation, diet, electromagnetic fields, exercise, light, sound, and the highly effective Serotonin Selective Reuptake Inhibitors (SSRI).

Penicillamine Protocol: D-Pen Mineral Provocation Test for Essential & Heavy (Toxic) Metals

This paper, based on the work of Dr. Russell M. Jaffe, discusses a method to determine the body’s burden of mobilizable potentially toxic minerals while simultaneously illustrating an assessment mechanism for nutritional divalent mineral status. Select the above listed title for the full paper, or click here for the two-page summary.

In order to determine the body’s burden of mobilizable, potentially toxic minerals, this Penicillamine Protocol has been developed involving a short (3-day) course of d-penicillamine or Acetyl-d-penicillamine with specimin collection and testing. Included in this paper is a suggested treatment guide to reduce total toxic mineral tissue burden which is comprised of nutritional supplementation and dietary recommendations.

Fibromyalgia Study

A novel treatment for Fibromyalgia improves clinical outcomes in a community-based study.

Fibromyalgia syndrome (FMS) is an increasingly common diagnosis of unknown etiology whose pathophysiology is still poorly understood. Since 1990, when the American College of Rheumatology (ACR) published classification criteria for FMS, it has been shown that FMS is quite prevalent (5-10%); women account for more than 70% of the diagnosis. Several suggestions have been made concerning FMS’s etiology, including abnormalities in central nervous system neurotransmitter concentrations.

Briefing for Primary Prevention

Real savings and productivity gains, measured and documented.

A presentation on how Primary Prevention can change U.S. Healthcare for the better. Whereas, the U.S. spends more than any country on healthcare); Employers pay over one-third of the costs which therefore reduces the competitiveness of American goods and services in the global marketplace; National health expenditure growth trends are likely to continue and these expenditures as percentage of GDP are growing in an unsustainable manner. Fundamentally with Primary Prevention, by improving the health and well-being of employees, quality of life is improved. Simultaneously, health care utilization and costs are reduced while disability is controlled and productivity enhanced. …

Biotic Relations

Anthropogenic relation to other biota: Connections to disorders and crises of our time.

Healthcare – A Comprehensive View

Speeding the transition to quality, affordable, and sustainable personal and societal health, through cross-disciplinary consilience and cross-cultural collaboration.

Proactive Prevention Adds Value

Proactive prevention adds value to all assets, “spend smarter, function better”

Tolerance Loss in Diabetics: Association with Foreign Antigen Exposure

Letter published in the journal compilation of Diabetec Medicine.

Xenobiotics: Managing Toxic Metals, Biocides, Hormone Mimics, Solvents, and Chemical Disruptors

Chapter excerpt from Ingrid Kohlstadt’s book “Scientific Evidence for Musculoskeletal, Bariatric, and Sports Nutrition”

First Line Comprehensive Care. Part II: Anthropogenic Xenobiotics in Functional Medicine

Managing Persisting Bioaccumulating Pollutants: Toxic Minerals, Biocides, Hormone Mimics, Solvents, and Chemical Disruptors

Inflammation is Repair Deficit

The Alkaline Way to Evoke Healing Response

The Alkaline Way: Integrative Management of Autoimmune Conditions

Article published in the Townsend Letter for Doctors and Patient

Acid-Alkaline Imbalance and its Effect on Bone Health

Acid-Alkaline Imbalance and its Effect on Bone Health

Article published in the International Journal of Integrative Medicine

Proactive Primary Prevention: Evidence of Savings Through Use of Supplements to Treat Dietary Deficiencies

Presentation to the National Health Research Institute, 6th Annual Scientific Symposium. Click here to review the symposium program.

Soft Energy Paths for the 21st Century

An article addressing power and policy in the post-Fukushima world

Research Conducted and Papers Prepared Non-Fellows

Content pending




Californians Health Alliance

A Proactive Preventive Health Care program that seeks to use a Public-Private Partnership model.

Sustainable Community Vital Signs

A project dedicated to stabilizing neighborhoods and improving the health and financial management skills of renters in affordable and government assisted housing.